https://doi.org/10.4081/bse.122
In vitro models of human cardiac fibrotic tissue on bioartificial scaffolds
Published: 14 February 2020
Abstract Views: 680
PDF: 333
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Cardiac infarction is a global burden worldwide that leads to fibrotic and not contractile myocardial tissue. In this work, in vitro models of infarcted tissue were developed as tools to test novel therapies for cardiac regeneration in the future. Human cardiac fibroblasts were cultured on scaffolds, with different compositions and architectures, as to mimic structural and chemical features of infarcted cardiac tissue. Early findings from in vitro cell tests were reported, showing an enhancement of cell attachment and proliferation in the case of bioartificial scaffolds, i.e. scaffolds based on a synthetic and a bioactive polymer.
How to Cite
Zoso, A., Carmagnola, I., Ruocco, G., Spedicati, M., & Chiono, V. (2020). In vitro models of human cardiac fibrotic tissue on <i>bioartificial</i> scaffolds. Biomedical Science and Engineering, 1(1). https://doi.org/10.4081/bse.122
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