Communications
29 September 2021
Vol. 2 No. 1 (2021)
https://doi.org/10.4081/bse.172

Drug-induced hepatotoxicity studied in a 3D, in vitro model of the liver

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Hepatotoxicity, in vitro models, 3D models, alternative models
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Authors

Giuseppe Guagliano
giuseppe.guagliano@polimi.it
Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Milan, Italy.
Manuela Legnardim
Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Milan, Italy.
Cristina Volpini
Molecular Medicine Department (DMM), Center for Health Technologies (CHT), UdR INSTM, University of Pavia, Pavia, Italy.
Nora Bloise
Molecular Medicine Department (DMM), Center for Health Technologies (CHT), UdR INSTM, University of Pavia, Pavia, Italy.
Silvia Dotti
National Reference Center for Alternative Methods, Welfare and Care of Laboratory Animals, Istituto Zooprofilattico Sperimentale della Lomabardia ed Emilia Romagna, Brescia, Italy.
Riccardo Villa
National Reference Center for Alternative Methods, Welfare and Care of Laboratory Animals, Istituto Zooprofilattico Sperimentale della Lomabardia ed Emilia Romagna, Brescia, Italy.
Livia Visai
Molecular Medicine Department (DMM), Center for Health Technologies (CHT), UdR INSTM, University of Pavia, Pavia; Medicina Clinica-Specialistica, UOR5 Laboratorio di Nanotecnologie, ICS Maugeri, IRCCS Pavia, Italy.
Paola Petrini
Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Milan, Italy.

Drug development is a high failure rate process; too many drugs fail during clinical trials because of severe hepatotoxicity. This situation can be significantly improved by redesigning preclinical trials, and privileging the use of high-throughput in vitro models, by combining cell-based in vitro models and material-based models.

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Drug-induced hepatotoxicity studied in a 3D, in vitro model of the liver. (2021). Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.172

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