https://doi.org/10.4081/bse.123
Reconstituted epithelial tissues and native cornea: A comparison of the influence of surfactants on ocular permeability
Published: 14 February 2020
Abstract Views: 549
PDF: 250
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The aim of this study was to prepare an artificial rabbit corneal epithelium (RRCE) to compare with a human corneal epithelial model and excised rabbit cornea through permeation studies to investigate differences of surfactants influence on ocular permeability of a lipophilic compound. First solubility assays with different surfactants were performed and the integrity of the RRCE was assessed by measuring transepithelial electrical resistance (TEER). The permeation parameters showed that the RRCE was more sensitive than native cornea and human cornal epithelial model to the effect of permeation enhancers.
How to Cite
Zucchetti, E., Monti, D., Chetoni, P., Tampucci, S., & Burgalassi, S. (2020). Reconstituted epithelial tissues and native cornea: A comparison of the influence of surfactants on ocular permeability. Biomedical Science and Engineering, 1(1). https://doi.org/10.4081/bse.123
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