Original Articles
12 February 2020
Vol. 1 No. 1 (2020)
https://doi.org/10.4081/bse.98

Platelet rich plasma enhancement of skin regeneration in an ex vivo human experimental model

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Platelet rich plasma, Regeneration, ex vivo, collagen, elastic fibers
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Authors

Giovanni Nicoletti
giovanni.nicoletti@unipv.it
Plastic and Reconstructive Surgery, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia; Plastic and Reconstructive Surgery Unit, Department of Surgery, Istituti Clinici Scientifici Maugeri, Pavia, Italy.
Marco Saler
Plastic and Reconstructive Surgery, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
Laura Villani
Agnese Rumolo
Plastic and Reconstructive Surgery, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
Marco Mario Tresoldi
Plastic and Reconstructive Surgery, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia; Plastic and Reconstructive Surgery Unit, Department of Surgery, Istituti Clinici Scientifici Maugeri, Pavia, Italy.
Angela Faga
Advanced Technologies for Regenerative Medicine and Inductive Surgery Research Center, University of Pavia, Pavia, Italy.

An original ex vivo wounded skin culture protocol using autologous Platelet Rich Plasma (PRP) and enriched Dulbecco’s Modified Eagle’s Medium demonstrated a favourable modulation of the epithelial cells and fibroblasts proliferation, a relevant antiinflammatory action and a favourable modulation of the re-organization of collagen and elastic fibres. The step by step regenerative effects of PRP on human skin wound repair and regeneration process was observed over a period of 10 days.

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Platelet rich plasma enhancement of skin regeneration in an ex vivo human experimental model. (2020). Biomedical Science and Engineering, 1(1). https://doi.org/10.4081/bse.98
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