Recellularization of decellularized porcine caval veins


https://doi.org/10.4081/bse.181
Vol. 2 No. 1 (2021)
Published: 29 September 2021
Decellularization, endothelial cell (EC) repopulation, bioreactor, tissue engineered blood vessels (TEBV)
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Authors

  • Maria Stefania Massaro
    maria.massaro@lfp.cuni.cz
    Biomedical Center, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czechia.
  • Richard Pálek Biomedical Center, Charles University, Faculty of Medicine in Pilsen, Pilsen; Department of Surgery, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czechia.
  • Jáchym Rosendorf Biomedical Center, Charles University, Faculty of Medicine in Pilsen, Pilsen; Department of Surgery, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czechia.
  • Anna Malečková Department of Histology and Embryology, Charles University, Faculty of Medicine in Pilsen, Pilsen; NTIS, Faculty of Applied Sciences, University of West Bohemia, Pilsen, Czechia.
  • Lenka Červenková Biomedical Center, Charles University, Faculty of Medicine in Pilsen, Pilsen; Department of Pathology, Third Faculty of Medicine, Charles University, Prague, Czechia.
  • Roshan K. Singh Biomedical Center, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czechia.
  • Robert Polák Biomedical Center, Charles University, Faculty of Medicine in Pilsen, Pilsen; Department of Surgery, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czechia.
  • Václav Liška Biomedical Center, Charles University, Faculty of Medicine in Pilsen, Pilsen; Department of Surgery, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czechia.
  • Vladimíra Moulisová Biomedical Center, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czechia.

Decellularized material has been reported to be more suitable for cells to grow when compared to synthetic materials because repopulating cells are provided with the structural environment of native tissue. The aim of this study is to prepare and to test porcine caval veins through their decellularization followed by repopulation with human endothelial cells.


Massaro, M. S., Pálek, R., Rosendorf, J., Malečková, A., Červenková, L., Singh, R. K., Polák, R., Liška, V., & Moulisová, V. . (2021). Recellularization of decellularized porcine caval veins . Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.181

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