Effects of occupational exposure to glyphosate in winegrowers

  • Melissa Ferrian Department of Diagnostics and Public Health, Section of Occupational Medicine, University of Verona, Verona, Italy.
  • Antonella Annicchiarico Postgraduate School of Occupational Medicine, University of Verona, Verona, Italy.
  • Mario Oliveri Department of Diagnostics and Public Health, Section of Occupational Medicine, University of Verona, Verona, Italy.
  • Claudio Colosio Department of Health Sciences, University of Milan, Milan, Italy.
  • Emanuela Corsini Department of Environmental Sciences and Politics, University of Milan, Milan, Italy.
  • Alessandra Barassi Department of Health Sciences, University of Milan, Milan, Italy.
  • Giuseppe Mastrangelo Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy.
  • Emanuela Fadda Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy.
  • Manuela Peruzzi Unit of Injury Prevention, SPISAL ULSS 9 Scaligera, Verona, Italy.
  • Stefano Porru | stefano.porru@univr.it Department of Diagnostics and Public Health, Section of Occupational Medicine, University of Verona, Verona; University Research Center “Integrated Models for Prevention and Protection in Environmental and Occupational Health” MISTRAL Universities of Brescia, Milano Bicocca and Verona, Italy.

Abstract

Glyphosate is a non-selective systemic herbicide used in agriculture. For almost half a century, the International Agency for Research on Cancer has run a Monographs program, the conclusion in March 2015 that glyphosate is “probably carcinogenic to humans” in addition to being genotoxic and carcinogenic in animals, while the regulatory European Food Safety Authority have asserted that glyphosate poses no public risk. The scientific debate is still lively. We collected detailed socio-demographic, occupational exposures and health surveillance information for 26 winegrowers as aim to investigate exposure to glyphosate and other pesticide. Exposure was assessed through biological monitoring (24-hour urine collection), immune function (IL-4, IL-5, IL-8, IL-12, IL- 17, IL-33, IFN- γ), transcriptional and post transcriptional alterations (miRNA) and genotoxic effects (Comet assay). The exposure conditions in our winegrowers, as referred to the parameters so far analyzed, did not reveal a significant glyphosate absorption nor significant health concerns.

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Published
2020-02-14
Keywords:
Glyphosate, winegrowers, comet assay, miRNA, immune function
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How to Cite
Ferrian, M., Annicchiarico, A., Oliveri, M., Colosio, C., Corsini, E., Barassi, A., Mastrangelo, G., Fadda, E., Peruzzi, M., & Porru, S. (2020). Effects of occupational exposure to glyphosate in winegrowers. Biomedical Science and Engineering, 3(s3). https://doi.org/10.4081/bse.2019.110