Original Articles
14 February 2020
Vol. 1 No. 1 (2020)
https://doi.org/10.4081/bse.111

Versatile electrical stimulator for providing cardiac-like electrical impulses in vitro

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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Electrical stimulation, cardiac tissue engineering, in vitro models, versatility
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Authors

Stefano Gabetti
PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy; Interuniversity Center for the Promotion of the 3Rs Principles in Teaching and Research, Italy, Italy.
Giovanni Putame
PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin; Interuniversity Center for the promotion of the 3Rs principles in teaching and research, Italy.
Federica Montrone
PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin; Interuniversity Center for the promotion of the 3Rs principles in teaching and research, Italy.
Giuseppe Isu
Department of Surgery and Department of Biomedicine, Basel University Hospital, Basel, Switzerland.
Anna Marsano
Department of Surgery and Department of Biomedicine, Basel University Hospital, Basel, Switzerland.
Alberto Audenino
PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin; Interuniversity Center for the promotion of the 3Rs principles in teaching and research, Italy.
Diana Massai
diana.massai@polito.it
PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin; Interuniversity Center for the promotion of the 3Rs principles in teaching and research, Italy.

In the perspective of reliable methods alternative to in vivo animal testing for cardiac tissue engineering (CTE) research, the versatile electrical stimulator ELETTRA has been developed. ELETTRA delivers controlled and stable cardiac-like electrical impulses, and it can be coupled to already existing bioreactors for providing in vitro combined biomimetic culture conditions. Designed to be cost-effective and easy to use, this device could contribute to the reduction and replacement of in vivo animal experiments in CTE.

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Versatile electrical stimulator for providing cardiac-like electrical impulses in vitro. (2020). Biomedical Science and Engineering, 1(1). https://doi.org/10.4081/bse.111

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