https://doi.org/10.4081/bse.110

Effects of occupational exposure to glyphosate in winegrowers

Vol. 1 No. 1 (2020)
Published: 14 February 2020
Glyphosate, winegrowers, comet assay, miRNA, immune function
Abstract Views: 595
PDF: 315
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Authors

Melissa Ferrian
Department of Diagnostics and Public Health, Section of Occupational Medicine, University of Verona, Verona, Italy.
Antonella Annicchiarico
Postgraduate School of Occupational Medicine, University of Verona, Verona, Italy.
Mario Oliveri
Department of Diagnostics and Public Health, Section of Occupational Medicine, University of Verona, Verona, Italy.
Claudio Colosio
Department of Health Sciences, University of Milan, Milan, Italy.
Emanuela Corsini
Department of Environmental Sciences and Politics, University of Milan, Milan, Italy.
Alessandra Barassi
Department of Health Sciences, University of Milan, Milan, Italy.
Giuseppe Mastrangelo
Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy.
Emanuela Fadda
Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy.
Manuela Peruzzi
Unit of Injury Prevention, SPISAL ULSS 9 Scaligera, Verona, Italy.
Stefano Porru
stefano.porru@univr.it
Department of Diagnostics and Public Health, Section of Occupational Medicine, University of Verona, Verona; University Research Center “Integrated Models for Prevention and Protection in Environmental and Occupational Health” MISTRAL Universities of Brescia, Milano Bicocca and Verona, Italy.

Glyphosate is a non-selective systemic herbicide used in agriculture. For almost half a century, the International Agency for Research on Cancer has run a Monographs program, the conclusion in March 2015 that glyphosate is “probably carcinogenic to humans†in addition to being genotoxic and carcinogenic in animals, while the regulatory European Food Safety Authority have asserted that glyphosate poses no public risk. The scientific debate is still lively. We collected detailed socio-demographic, occupational exposures and health surveillance information for 26 winegrowers as aim to investigate exposure to glyphosate and other pesticide. Exposure was assessed through biological monitoring (24-hour urine collection), immune function (IL-4, IL-5, IL-8, IL-12, IL- 17, IL-33, IFN- γ), transcriptional and post transcriptional alterations (miRNA) and genotoxic effects (Comet assay). The exposure conditions in our winegrowers, as referred to the parameters so far analyzed, did not reveal a significant glyphosate absorption nor significant health concerns.

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How to Cite

Ferrian, M., Annicchiarico, A., Oliveri, M., Colosio, C., Corsini, E., Barassi, A., … Porru, S. (2020). Effects of occupational exposure to glyphosate in winegrowers. Biomedical Science and Engineering, 1(1). https://doi.org/10.4081/bse.110

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