In vitro models of human cardiac fibrotic tissue on ‘bioartificial’ scaffolds

  • Alice Zoso Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin; Interuniversity Center for the promotion of the 3Rs principles in teaching and research, Italy.
  • Irene Carmagnola Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin; CNR-IPCF, National Research Council – Institute for Chemical and Physical Processes, Pisa, Italy.
  • Gerardina Ruocco Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin; POLITO Biomedlab, Politecnico di Torino, Turin, Italy.
  • Mattia Spedicati Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin; POLITO Biomedlab, Politecnico di Torino, Turin, Italy.
  • Valeria Chiono | valeria.chiono@polito.it Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin; CNR-IPCF, National Research Council – Institute for Chemical and Physical Processes, Pisa, Italy.

Abstract

Cardiac infarction is a global burden worldwide that leads to fibrotic and not contractile myocardial tissue. In this work, in vitro models of infarcted tissue were developed as tools to test novel therapies for cardiac regeneration in the future. Human cardiac fibroblasts were cultured on scaffolds, with different compositions and architectures, as to mimic structural and chemical features of infarcted cardiac tissue. Early findings from in vitro cell tests were reported, showing an enhancement of cell attachment and proliferation in the case of “bioartificial” scaffolds, i.e. scaffolds based on a synthetic and a bioactive polymer.

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Published
2020-02-14
Keywords:
Biomimetic scaffolds, extracellular matrix, in vitro human cardiac fibrotic tissue model
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How to Cite
Zoso, A., Carmagnola, I., Ruocco, G., Spedicati, M., & Chiono, V. (2020). In vitro models of human cardiac fibrotic tissue on ‘bioartificial’ scaffolds. Biomedical Science and Engineering, 3(s3). https://doi.org/10.4081/bse.2019.122