Health monitoring program for the control of laboratory animal diseases

  • Chiara Romano | chiara.romano@izsler.it Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna (IZSLER), Centro di Referenza Nazionale per i Metodi Alternativi, Benessere e Cura degli Animali da Laboratorio, Brescia, Italy.
  • Andrea Cacciamali Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna (IZSLER), Centro di Referenza Nazionale per i Metodi Alternativi, Benessere e Cura degli Animali da Laboratorio, Brescia, Italy.
  • Silvia Dotti Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna (IZSLER), Centro di Referenza Nazionale per i Metodi Alternativi, Benessere e Cura degli Animali da Laboratorio, Brescia, Italy.
  • Riccardo Villa Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna (IZSLER), Centro di Referenza Nazionale per i Metodi Alternativi, Benessere e Cura degli Animali da Laboratorio, Brescia, Italy.

Abstract

Pathogens present in the environment are the biggest source of diseases and epidemics in the breeding of laboratory animals. In fact, the presence of microorganisms can critically influence the animal health status and, consequently, the validity and reproducibility of experimental data. In accordance with the 3Rs principle (Refinement, Reduction, Replacement), this study is part of the Refinement concept. The FELASA guidelines, formulated with the aim of guaranteeing the best animal health state, are a valid support for researchers. In this preliminary study, health-monitoring program was carried out within the breeding of laboratory animals in IZSLER facility. The main murine viruses were analyzed through molecular biology techniques (PCR, RT-PCR) and enzyme immunoassays (indirect ELISA). The established surveillance program steadily guarantees animal health and ensures the most controlled environmental and sanitary conditions. Further investigations will be needed to develop virus control strategies.

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Published
2020-02-14
Keywords:
Health-monitoring, 3R's principle, rodents' breeding, molecular analysis, serological analysis
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How to Cite
Romano, C., Cacciamali, A., Dotti, S., & Villa, R. (2020). Health monitoring program for the control of laboratory animal diseases. Biomedical Science and Engineering, 3(s3). https://doi.org/10.4081/bse.2019.117