Analysis of non-animal methods and models for research in cardiovascular disease

  • Emanuele Gasparotti BioCardioLab, Bioengineering Unit, Fondazione Toscana G. Monasterio, Massa; Department of Information Engineering, University of Pisa, Pisa, Italy.
  • Margherita Cioffi RINA Consulting S.p.a, Rome, Italy.
  • Vincenzo Positano BioCardioLab, Bioengineering Unit, Fondazione Toscana G. Monasterio, Massa, Italy.
  • Emanuele Vignali BioCardioLab, Bioengineering Unit, Fondazione Toscana G. Monasterio, Massa; Department of Information Engineering, University of Pisa, Pisa, Italy.
  • Benigno Marco Fanni BioCardioLab, Bioengineering Unit, Fondazione Toscana G. Monasterio, Massa; Department of Information Engineering, University of Pisa, Pisa, Italy.
  • Katia Capellini BioCardioLab, Bioengineering Unit, Fondazione Toscana G. Monasterio, Massa; Department of Information Engineering, University of Pisa, Pisa, Italy.
  • Dorela Haxhiademi Anesthesia and ICU Department, Heart Hospital, Fondazione Toscana G. Monasterio, Massa, Italy.
  • Emiliano Costa RINA Consulting S.p.a, Rome, Italy.
  • Sergio Berti Adult Cardiology Unit, Heart Hospital, Fondazione Toscana G. Monasterio, Massa, Italy.
  • Luigi Landini BioCardioLab, Bioengineering Unit, Fondazione Toscana G. Monasterio, Massa; Department of Information Engineering, University of Pisa, Pisa, Italy.
  • Simona Celi | s.celi@ftgm.it BioCardioLab, Bioengineering Unit, Fondazione Toscana G. Monasterio, Massa, Italy.
  • Laura Gribaldo European Commission, DG Joint Research Centre, Ispra, VA, Italy.

Abstract

Cardiovascular diseases (CVD) are disorders of the heart and blood vessels and represent 31% of all global deaths. In the contest of CVD, the use of animal experiments has been a contentious subject for many years. In recent years, in vitro and in silico models and methods have been proposed according to the 3Rs statement. However, an exhaustive report regarding the state of art in terms of in vitro and in silico experiments has not been reported yet. This work is focused on providing a collection of non-animal models and methods in use for basic and applied CVD research. The standardized descriptions of such studies will ultimately feed into EURL ECVAM database on alternative methods. Two are the research main phases. Firstly, the exclusion/ inclusion criteria and the list of relevant information resources of the research have been defined. The second phase regards the search, selection and detailed description of the literature papers by analysing records on Scopus and Pubmed databases.

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Published
2020-02-14
Keywords:
Cardiovascular diseases, non-animal methods, state of art, in silico, in vitro
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How to Cite
Gasparotti, E., Cioffi, M., Positano, V., Vignali, E., Fanni, B. M., Capellini, K., Haxhiademi, D., Costa, E., Berti, S., Landini, L., Celi, S., & Gribaldo, L. (2020). Analysis of non-animal methods and models for research in cardiovascular disease. Biomedical Science and Engineering, 3(s3). https://doi.org/10.4081/bse.2019.112