Stress-induced premature senescence in hiPSC-derived cardiomyocytes recapitulates aging-induced cardiac remodelling


Published: 17 November 2023
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Authors

  • E. Lazzarini Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
  • A. M. Lodrini Department of Biotechnology and Biosciences, Università degli Studi di Milano-Bicocca, Italy; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.
  • M. Arici Department of Biotechnology and Biosciences, Università degli Studi di Milano-Bicocca, Italy.
  • S. Bolis Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona; Cellular and Molecular Cardiology, Istituto Cardiocentro Ticino, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
  • S. Vagni Department of Biotechnology and Biosciences, Università degli Studi di Milano-Bicocca, Italy.
  • S. Panella Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
  • A. Rendon-Angel Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.
  • M. Saibene Department of Earth and Environmental Sciences, Università degli Studi di Milano-Bicocca, Milano, Italy.
  • A. Metallo Department of Biotechnology and Biosciences, Università degli Studi di Milano-Bicocca, Italy.
  • T. Torre Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.
  • G. Vassalli Cellular and Molecular Cardiology, Istituto Cardiocentro Ticino, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.
  • P. Ameri Cardiovascular Disease Unit, IRCCS Ospedale Policlinico, Genova; Department of Internal Medicine, University of Genova, Italy.
  • C. Altomare Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
  • M. Rocchetti Department of Biotechnology and Biosciences, Università degli Studi di Milano-Bicocca, Italy.
  • L. Barile Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland;Institute of Life Science, Scuola Superiore Sant’Anna, Pisa, Italy.

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Lazzarini, E., Lodrini, A. M., Arici, M., Bolis, S., Vagni, S., Panella, S., Rendon-Angel, A., Saibene, M., Metallo, A., Torre, T., Vassalli, G., Ameri, P., Altomare, C., Rocchetti, M., & Barile, L. (2023). Stress-induced premature senescence in hiPSC-derived cardiomyocytes recapitulates aging-induced cardiac remodelling. Biomedical Science and Engineering, 5(1). https://doi.org/10.4081/bse.230

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