Communications
29 September 2021
Vol. 2 No. 1 (2021)
In silico investigation of molecular interactions of volatile anesthetics: effects on phospholipid membranes and subcellular targets
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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The ability of anesthetics to reversibly suppress consciousness must reside in the effects exerted onto specific molecular targets. Interactions between volatile anesthetics and the phospholipid membrane as well as intracellular tubulin, were investigated using Computational Molecular Modelling, which showed rapid ligand partitioning inside the membrane and significant effects on the mechanical characteristics thereof, while transient binding locations have been found on the tubulin dimer.
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In silico investigation of molecular interactions of volatile anesthetics: effects on phospholipid membranes and subcellular targets. (2021). Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.202
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