Communications
29 September 2021
Vol. 2 No. 1 (2021)
https://doi.org/10.4081/bse.179

Toward scalable in vitro models: a novel experimental and computational pipeline for the identification of cellular metabolic parameters

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In vitro models, 2D cell cultures, oxygen consumption rate, parameter identification
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Authors

Piera Mancini
p.mancini1@studenti.unipi.it
Research Center “E. Piaggio”, University of Pisa, Pisa, Italy.
Ermes Botte
Research Center “E. Piaggio”, University of Pisa, Pisa; Department of Information Engineering, University of Pisa, Pisa, Italy.
Chiara Magliaro
Research Center “E. Piaggio”, University of Pisa, Pisa, Italy.
Arti Ahluwalia
Research Center “E. Piaggio”, University of Pisa, Pisa; Department of Information Engineering, University of Pisa, Pisa, Italy.

Oxygen utilization by cells has a crucial role in the design of advanced in vitro models. The aim of this study is to develop an experimental and computational pipeline for identifying oxygen metabolism parameters. We applied the approach to HepG2 cell monolayer cultures, demonstrating that such parameters depend on cell density.

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Toward scalable in vitro models: a novel experimental and computational pipeline for the identification of cellular metabolic parameters. (2021). Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.179

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