Communications
29 September 2021
Vol. 2 No. 1 (2021)
https://doi.org/10.4081/bse.166

Towards reliable in vitro models. New bi-compartmental platforms for replicating tissue barriers

Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Cell cultures, laser cutting, bicompartmental, reuse, in vitro tissue models, tissue barriers
405
Views
223
Downloads

Authors

Lorenzo P. Coppadoro
lorenzopietro.coppadoro@polimi.it
Department of Electronics, Information and Bioengineering, Politecnico di Milano, Italy.
Elia Pederzani
Department of Electronics, Information and Bioengineering, Politecnico di Milano, Italy.
Chiara Foglieni
Cardiovascular Research Area, IRCCS San Raffaele Scientific Institute, Milano, Italy.
Maria Lombardi
Cardiovascular Research Area, IRCCS San Raffaele Scientific Institute, Milano, Italy.
Gianfranco B. Fiore
Department of Electronics, Information and Bioengineering, Politecnico di Milano, Italy.
Monica Soncini
Department of Electronics, Information and Bioengineering, Politecnico di Milano, Italy.

In vitro cell cultures represent a widespread methodology for pathophysiology studies with a high benefit/cost ratio. We have developed and are validating TToP, a novel, versatile, and scalable culture system allowing compartmentalized cell/tissue cultures with the aim of mimicking the human pathophysiological microenvironment of tissue barriers.

Altmetrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Paul SM, Mytelka DS, Dunwiddie CT, et al. How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nat Rev Drug Discov 2010;9:203-14.
Astashkina A, Mann B, Grainger DW. A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity. Pharmacol Ther 2012;134:82-106.
Walsh III D.I. Kong DS, Murthy SK, Carr PS. Enabling Microfluidics: from Clean Rooms to Makerspaces. Trends Biotechnol2017;35:383-92.
Ren Y, Ray S, Liu Y. Reconfigurable Acrylic-tape Hybrid Microfluidics. Sci Rep. 2019;9:4824.

How to Cite



Towards reliable in vitro models. New bi-compartmental platforms for replicating tissue barriers. (2021). Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.166
Copyright (c) 2021 The Authors Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.