Development and characterization of a novel human 3D model of bone metastasis from breast carcinoma in vitro cultured


Published: 29 September 2021
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Authors

  • Deyanira Contartese Complex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Francesca Salamanna Complex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Veronica Borsari Complex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Stefania Pagani Complex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Maria Sartori Complex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Lucia Martini Complex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Giovanni Barbanti Brodano Spine Surgery Prevalently Oncologic and Degenerative, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Alessandro Gasbarrini Spine Surgery Prevalently Oncologic and Degenerative, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Milena Fini Complex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Breast cancer frequently metastasizes to the skeleton causing significant morbidity. Here, we set-up a novel and advanced ex vivo model by using fresh tissue from human vertebral bone metastasis from breast carcinoma patients able to retain the tumor microenvironment and tumor cells heterogeneity.


Contartese, D., Salamanna, F., Borsari, V., Pagani, S., Sartori, M., Martini, L., Barbanti Brodano, G. ., Gasbarrini, A., & Fini, M. (2021). Development and characterization of a novel human 3D model of bone metastasis from breast carcinoma <em>in vitro</em> cultured. Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.165

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