Effect of manuka honey on 5-fluorouracil chemosensitivity in colonspheres enriched with cancer stem (-like) cells


Published: 29 September 2021
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Authors

  • Danila Cianciosi Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy, Italy.
  • Lucia Regolo Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy.
  • Maurizio Battino Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, China.
  • Francesca Giampieri Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy; Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Manuka honey (MH) has an in vitro chemosensitizing effect against 5-Fluorouracil (5-Fu) in colonspheres enriched with cancer stem (-like) cells (CSCs-like); these interesting findings, although preliminary, suggest a potential synergistic action of MH with 5-Fu, which could be useful in deepening the studies on natural compounds to be used in association with conventional medical therapies.


Cianciosi, D., Regolo, L., Battino, M., & Giampieri, F. (2021). Effect of manuka honey on 5-fluorouracil chemosensitivity in colonspheres enriched with cancer stem (-like) cells . Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.163

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