A millifluidic-based 3D-platform as a useful tool for the efficacy of glaucoma therapeutic strategies


Published: 28 September 2021
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Authors

  • Anna M. Bassi Department of Experimental Medicine (DIMES), University of Genoa; Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), Pisa, Italy.
  • Sara Tirendi Department of Experimental Medicine (DIMES), University of Genoa; Inter- University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), Pisa, Italy.
  • Sonia Scarfì Inter- University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), Pisa; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa, Italy.
  • Mario Passalacqua Department of Experimental Medicine (DIMES), University of Genoa; Inter- University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), Pisa, Italy.
  • Vanessa Almonti Department of Experimental Medicine (DIMES), University of Genoa; Inter- University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), Pi, Italy.
  • Stefania Vernazza Department of Experimental Medicine (DIMES), University of Genoa, Italy.

The aim of this present study is to investigate the role of damaged Trabecular Meshwork (TM) in triggering neuron-like cell apoptosis. Preliminary results showed that stressed TM releases harmful signals to neuron-like cells, suggesting its pivotal role in glaucoma cascade.


Bassi, A. M., Tirendi, S., Scarfì, S., Passalacqua, M., Almonti, V., & Vernazza, S. (2021). A millifluidic-based 3D-platform as a useful tool for the efficacy of glaucoma therapeutic strategies. Biomedical Science and Engineering, 3(1). https://doi.org/10.4081/bse.135

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