Original articles
28 September 2021
Vol. 3 No. 1 (2022)
https://doi.org/10.4081/bse.135

A millifluidic-based 3D-platform as a useful tool for the efficacy of glaucoma therapeutic strategies

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Glaucoma, in vitro model, trabecular meshwork
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Authors

Anna M. Bassi
anna.maria.bassi@unige.it
Department of Experimental Medicine (DIMES), University of Genoa; Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), Pisa, Italy.
Sara Tirendi
Department of Experimental Medicine (DIMES), University of Genoa; Inter- University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), Pisa, Italy.
Sonia Scarfì
Inter- University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), Pisa; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa, Italy.
Mario Passalacqua
Department of Experimental Medicine (DIMES), University of Genoa; Inter- University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), Pisa, Italy.
Vanessa Almonti
Department of Experimental Medicine (DIMES), University of Genoa; Inter- University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), Pi, Italy.
Stefania Vernazza
Department of Experimental Medicine (DIMES), University of Genoa, Italy.

The aim of this present study is to investigate the role of damaged Trabecular Meshwork (TM) in triggering neuron-like cell apoptosis. Preliminary results showed that stressed TM releases harmful signals to neuron-like cells, suggesting its pivotal role in glaucoma cascade.

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A millifluidic-based 3D-platform as a useful tool for the efficacy of glaucoma therapeutic strategies. (2021). Biomedical Science and Engineering, 3(1). https://doi.org/10.4081/bse.135
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